Stratification of ON and OFF ganglion cell dendrites depends on glutamate-mediated afferent activity in the developing retina

@article{Bodnarenko1993StratificationOO,
  title={Stratification of ON and OFF ganglion cell dendrites depends on glutamate-mediated afferent activity in the developing retina},
  author={Stefan R. Bodnarenko and Leo M. Chalupa},
  journal={Nature},
  year={1993},
  volume={364},
  pages={144-146}
}
A FUNDAMENTAL attribute of the vertebrate visual system is the segregation of ON and OFF pathways signalling increments and decrements of light1–4. In the mature retina, dendrites of ON- and OFF-centre retinal ganglion cells (RGCs) stratify in different sublaminae of the inner plexiform layer (IPL), and are differentially innervated by two types of bipolar cells which depolarize and hyperpolarize on exposure to light5–10. This stratification of ON and OFF RGCs is achieved by the gradual… CONTINUE READING
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