Strategy to diagnose monoclonal gammopathies in serum: high-resolution electrophoresis, immunofixation, and kappa/lambda quantification.

@article{Keren1988StrategyTD,
  title={Strategy to diagnose monoclonal gammopathies in serum: high-resolution electrophoresis, immunofixation, and kappa/lambda quantification.},
  author={David F.. Keren and Jeffrey S. Warren and John B. Lowe},
  journal={Clinical chemistry},
  year={1988},
  volume={34 11},
  pages={2196-201}
}
Identification of monoclonal gammopathies in serum has involved electrophoresis of serum proteins, immunoelectrophoresis (IEP), and quantification of IgG, IgA, and IgM. Recent innovations in technology--including high-resolution electrophoresis (HRE), immunofixation (IFX), and quantification of kappa- and lambda-containing immunoglobulins--allow for more rapid and precise assessment of serum for monoclonal proteins. We present a series of guidelines to determine when high-resolution… CONTINUE READING
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