Strategy to assess the efficiency of U1 RNA-hammerhead ribozyme constructs using GFP-tagged targets.


The application of ribozymes for gene therapy of autosomal dominant diseases has become popularized in recent years. Further this technology has widespread utility in the treatment of any disease, acquired or inherited, by inhibition of gene expression. The design of ribozymes is usually accomplished using computer assisted design programs, however they are… (More)


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