Strategy of Using Intratreatment Hypoxia Imaging to Selectively and Safely Guide Radiation Dose De-escalation Concurrent With Chemotherapy for Locoregionally Advanced Human Papillomavirus-Related Oropharyngeal Carcinoma.

@article{Lee2016StrategyOU,
  title={Strategy of Using Intratreatment Hypoxia Imaging to Selectively and Safely Guide Radiation Dose De-escalation Concurrent With Chemotherapy for Locoregionally Advanced Human Papillomavirus-Related Oropharyngeal Carcinoma.},
  author={N. Y. Louis Lee and Heiko Schoder and Brad J Beattie and Ryan M Lanning and Nadeem Riaz and Sean M. J. McBride and Nora Katabi and Duan Li and Brett B. Yarusi and Susie Chan and Lindsey R. Mitrani and Zhigang Zhang and David G. Pfister and Eric J Sherman and Shrujal S Baxi and Jay O. Boyle and Luc G T Morris and Ian Ganly and Richard J Wong and John L. Humm},
  journal={International journal of radiation oncology, biology, physics},
  year={2016},
  volume={96 1},
  pages={9-17}
}
PURPOSE To report a small substudy of an ongoing large, multi-arm study using functional imaging to assess pre-/intratreatment hypoxia for all head and neck cancer, in which we hypothesized that pre- and early-treatment hypoxia assessment using functional positron emission tomography (PET) imaging may help select which human papillomavirus (HPV)-positive (HPV(+)) oropharyngeal cancer (OPC) patients can safely receive radiation de-escalation without jeopardizing treatment outcomes. METHODS AND… CONTINUE READING
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