Strategy for analysing the co-operativity of intramolecular interactions in peptides and proteins.

@article{Horovitz1990StrategyFA,
  title={Strategy for analysing the co-operativity of intramolecular interactions in peptides and proteins.},
  author={Amnon Horovitz and A. R. Fersht},
  journal={Journal of molecular biology},
  year={1990},
  volume={214 3},
  pages={
          613-7
        }
}
Double mutant cycles enable the measurement of pairwise interactions in proteins. This method is extended for mutations at any number of positions in the protein. This provides a way for determining the context dependence of pairwise interactions on other neighbouring residues. 

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