Strategy for achieving selective killing of carcinomas.

  title={Strategy for achieving selective killing of carcinomas.},
  author={Robert I. Garver and Kimberly Goldsmith and Brad Rodu and Peter C. Hu and Eric Sorscher and David T. Curiel},
  journal={Gene therapy},
  volume={1 1},
Carcinomas are malignancies derived from epithelial cells that frequently respond poorly to conventional chemotherapy. Selective expression or transduction of toxin genes to carcinomas, i.e. molecular chemotherapy, may offer important advantages over conventional chemotherapy. As one approach to developing a means of selectively expressing toxin genes, the transcriptional regulatory sequences of a gene expressed in multiple carcinomas were used to direct expression of the herpes simplex virus… CONTINUE READING