Strategies to rescue cognitive deficits due to SYNGAP1 haploinsufficiency

  title={Strategies to rescue cognitive deficits due to SYNGAP1 haploinsufficiency},
  author={Martin H. Berryer and F. Hamdan and G. Cristo and J. Michaud},
  journal={International Journal of Developmental Neuroscience},
  • Martin H. Berryer, F. Hamdan, +1 author J. Michaud
  • Published 2015
  • Medicine
  • International Journal of Developmental Neuroscience
  • in utero cyanosis. Our studies have shown that WM-immaturity causes increased oligodendrocyte apoptosis following ischemiareperfusion/reoxygenation (I/R). Astrocytes play a central role in brain protection. Using our rodent brain-slice model, we investigated: (i) the role of astrocytes in reducing WM-injury after surgery; and (ii) the effects of preoperative-cyanosis on this role. Methods: To replicate in utero cyanosis, GFAP-GFP mice were exposed to hypoxia (10.5% FiO2) from day 3 to 11 which… CONTINUE READING