Strategies to overcome obstacles to successful immunotherapy of melanoma.

@article{Pandolfi2008StrategiesTO,
  title={Strategies to overcome obstacles to successful immunotherapy of melanoma.},
  author={Franco Pandolfi and Rossella Cianci and Silvano Lolli and I. P. S. Dunn and Estelle E. Newton and Timothy J. Haggerty and Lenora A. Boyle and James T. Kurnick},
  journal={International journal of immunopathology and pharmacology},
  year={2008},
  volume={21 3},
  pages={
          493-500
        }
}
The immunogenicity of malignant melanomas has been recognized by the observed recruitment of tumor-specific cytotoxic T-cells (CTL), leading to the identification of several melanoma associated antigen (MAA). However, numerous strategies to treat melanoma with immunotherapy have resulted in only partial success. In this editorial, we discuss recent data related to the ability of tumors to elude immune responses. We therefore discuss different strategies to induce a clinically effective immune… CONTINUE READING
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