Strategies to increase the reproducibility of protein fibrillization in plate reader assays.


There is great interest in developing reproducible high-throughput screens to identify small molecular inhibitors of protein fibrillization and aggregation for possible therapy against deposition diseases such as Alzheimer's and Parkinson's (PD). We have made a methodical analysis of factors increasing the reproducibility of the fibrillization of alpha… (More)
DOI: 10.1016/j.ab.2010.02.001