Strategies to identify the Lynch syndrome among patients with colorectal cancer: a cost-effectiveness analysis.

@article{Ladabaum2011StrategiesTI,
  title={Strategies to identify the Lynch syndrome among patients with colorectal cancer: a cost-effectiveness analysis.},
  author={Uri Ladabaum and Grace Wang and Jonathan P. Terdiman and Amie M. Blanco and Miriam Kuppermann and Clement Richard Boland and James M. Ford and Elena E Elkin and Kathryn A. Phillips},
  journal={Annals of internal medicine},
  year={2011},
  volume={155 2},
  pages={69-79}
}
BACKGROUND Testing has been advocated for all persons with newly diagnosed colorectal cancer to identify families with the Lynch syndrome, an autosomal dominant cancer-predisposition syndrome that is a paradigm for personalized medicine. OBJECTIVE To estimate the effectiveness and cost-effectiveness of strategies to identify the Lynch syndrome, with attention to sex, age at screening, and differential effects for probands and relatives. DESIGN Markov model that incorporated risk for… CONTINUE READING
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