Strategies to address low drug solubility in discovery and development.

@article{Williams2013StrategiesTA,
  title={Strategies to address low drug solubility in discovery and development.},
  author={Hywel D Williams and Natalie L Trevaskis and Susan A. Charman and Ravi Mysore Shanker and William Neil Charman and Colin W. Pouton and Christopher J. H. Porter},
  journal={Pharmacological reviews},
  year={2013},
  volume={65 1},
  pages={
          315-499
        }
}
Drugs with low water solubility are predisposed to low and variable oral bioavailability and, therefore, to variability in clinical response. Despite significant efforts to "design in" acceptable developability properties (including aqueous solubility) during lead optimization, approximately 40% of currently marketed compounds and most current drug development candidates remain poorly water-soluble. The fact that so many drug candidates of this type are advanced into development and clinical… CONTINUE READING

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