Strategies to Resolve the Catalytic Mechanism of Acetylcholinesterase


Acetylcholinesterase (AChE) hydrolyzes its physiological substrate acetylcholine at one of the highest known catalytic rates. Two sites of ligand interaction have been identified: an acylation site or A-site at the base of the active-site gorge and a peripheral site or P-site at its mouth. Although much is known about AChE structure and the role of specific… (More)
DOI: 10.1007/s12031-009-9250-3

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