Strategies to Obtain Diverse and Specific Human Monoclonal Antibodies From Transgenic Animals.

Abstract

Techniques to obtain large quantities of antigen-specific monoclonal antibodies (mAbs) were first established in the 1970s when Georges Köhler and César Milstein immortalized antibody-producing mouse B-lymphocytes by fusion with myeloma cells (http://www.whatisbiotechnology.org/exhibitions/milstein). Combined with the expression of human antibodies in… (More)
DOI: 10.1097/TP.0000000000001702

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