Strategies of protection from nitric oxide toxicity in islet inflammation

@article{Rothe1999StrategiesOP,
  title={Strategies of protection from nitric oxide toxicity in islet inflammation},
  author={H. Rothe and Hubert Kolb},
  journal={Journal of Molecular Medicine},
  year={1999},
  volume={77},
  pages={40-44}
}
  • H. RotheH. Kolb
  • Published 1999
  • Biology, Medicine
  • Journal of Molecular Medicine
Nitric oxide is thought to contribute to beta cell destruction during islet inflammation in animal models of type I diabetes. In vitro, inhibition of inducible nitric oxide synthase protects islet cells from the damaging effects of inflammatory cells or cytokines. However, the administration of several inducible nitric oxide synthase inhibitors to prediabetic animals had variable effects on disease progression. An alternative approach is to prevent the lethal consequences of nitric oxide action… 

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  • Biology, Medicine
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It is shown that exposure of an islet cell suspension to the NO donor nitroprusside or to activated macrophages leads to DNA strand breaks, which conclude that is let cell DNA is an early target of NO action.

Aminoguanidine, an inhibitor of nitric oxide formation, fails to protect against insulitis and hyperglycemia induced by multiple low dose streptozotocin injections in mice.

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