Strategies of protection from nitric oxide toxicity in islet inflammation

@article{Rothe1999StrategiesOP,
  title={Strategies of protection from nitric oxide toxicity in islet inflammation},
  author={H. Rothe and Hubert Kolb},
  journal={Journal of Molecular Medicine},
  year={1999},
  volume={77},
  pages={40-44}
}
  • H. RotheH. Kolb
  • Published 1999
  • Biology, Medicine
  • Journal of Molecular Medicine
Nitric oxide is thought to contribute to beta cell destruction during islet inflammation in animal models of type I diabetes. In vitro, inhibition of inducible nitric oxide synthase protects islet cells from the damaging effects of inflammatory cells or cytokines. However, the administration of several inducible nitric oxide synthase inhibitors to prediabetic animals had variable effects on disease progression. An alternative approach is to prevent the lethal consequences of nitric oxide action… 
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33 Citations

Cytotoxic Role of Nitric Oxide in Diabetes

Pathophysiological Roles of Nitric Oxide in Inflammation

Inducible Nitric Oxide Synthase and Inflammatory Diseases

This work focuses on the complex role of NO produced by the inducible form of nitric oxide synthase (iNOS) in inflammatory and autoimmune diseases and how various facets of the immune response can be examined.

The role of nitric oxide in inflammatory reactions.

This Minireview will discuss the role of NO in immune response and inflammation, and its mechanisms of action in these processes.

Effects of interleukin-15 on suppression of rat pancreatic islets in vitro induced by proinflammatory cytokines.

Leflunomide inhibits activation of inducible nitric oxide synthase in rat astrocytes

Nitric oxide and immune response.

  • P. Tripathi
  • Biology, Medicine
    Indian journal of biochemistry & biophysics
  • 2007
The role of NO in non-specific and specific immunity in vivo and in immunologically mediated diseases and inflammation is poorly understood.

The role of nitric oxide in in£ammatory reactions

This Minireview will discuss the role of NO in immune response and inflammation, and its mechanisms of action in these processes.

Contribution of adenoviral-mediated superoxide dismutase gene transfer to the reduction in nitric oxide-induced cytotoxicity on human islets and INS-1 insulin-secreting cells

It is established that adenoviral-induced overexpression of Cu/Zn SOD can be beneficial to human islet endocrine function and resistance to nitric oxide cytotoxicity and is relevant for the development of new strategies aimed at preventing NO-induced beta-cell damage in an islet transplantation setting.

Modulation of autoimmune diseases by nitric oxide

The role of NO and nitric oxide synthase (NOS) in pathophysiologic and therapeutic implications in various autoimmune diseases with particular reference to T helper-1 (Th1) and T helpers-2 (Th2) cytokines are discussed.

References

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