Strategies in maintenance for patients receiving long-term therapy (SIMPLE): a study of MMX mesalamine for the long-term maintenance of quiescent ulcerative colitis.

@article{Kane2012StrategiesIM,
  title={Strategies in maintenance for patients receiving long-term therapy (SIMPLE): a study of MMX mesalamine for the long-term maintenance of quiescent ulcerative colitis.},
  author={Soul{\`e}ye Kane and Seymour Katz and Mohammad Mazen Jamal and Michael A. Safdi and Ben Dolin and Dory Solomon and Mary J. H. J. Palmen and Karen B. Barrett},
  journal={Inflammatory bowel diseases},
  year={2012},
  volume={18 6},
  pages={
          1026-33
        }
}
BACKGROUND This was a phase IV, multicenter, open-label, 12-14-month study to assess clinical recurrence in patients with ulcerative colitis (UC) who received maintenance treatment with MMX Multi Matrix System (MMX) mesalamine. A secondary outcome was the relationship between long-term efficacy and adherence. METHODS Patients with quiescent UC (no rectal bleeding; 0-1 bowel movements more than normal per day) were enrolled directly into a 12-month maintenance phase of the study during which… CONTINUE READING
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