Strategies in case of positive in vivo results in genotoxicity testing.

  title={Strategies in case of positive in vivo results in genotoxicity testing.},
  author={V{\'e}ronique Thybaud and James T Macgregor and Lutz M{\"u}ller and Riccardo Crebelli and Kerry L. Dearfield and George Douglas and Peter B. Farmer and Elmar Gocke and Makoto Hayashi and David Paul Lovell and Werner K. Lutz and Daniel Marzin and Martha Moore and Takehiko Nohmi and David H Phillips and Jan van Benthem},
  journal={Mutation research},
  volume={723 2},
At the 2009 International Workshop on Genotoxicity Testing in Basel, an expert group gathered to provide guidance on suitable follow-up tests to describe risk when basic in vivo genotoxicity tests have yielded positive results. The working group agreed that non-linear dose-response curves occur in vivo with at least some DNA-reactive agents. Quantitative… CONTINUE READING