Strategies for transporting nanoparticles across the blood-brain barrier.

Abstract

The existence of blood-brain barrier (BBB) hampers the effective treatment of central nervous system (CNS) diseases. Almost all macromolecular drugs and more than 98% of small molecule drugs cannot pass the BBB. Therefore, the BBB remains a big challenge for delivery of therapeutics to the central nervous system. With the structural and mechanistic… (More)
DOI: 10.1039/c5bm00383k

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