Strategies for the discovery and engineering of enzymes for biocatalysis.

@article{Davids2013StrategiesFT,
  title={Strategies for the discovery and engineering of enzymes for biocatalysis.},
  author={Timo Davids and Matthias Schmidt and Dominique B{\"o}ttcher and Uwe T Bornscheuer},
  journal={Current opinion in chemical biology},
  year={2013},
  volume={17 2},
  pages={
          215-20
        }
}
Protein engineering is the most important method to overcome the limitations of natural enzymes as biocatalysts. The past few years have seen a tremendous increase in novel concepts to facilitate the design of mutant libraries for focused directed evolution mostly guided by advanced bioinformatic tools. In addition, advanced high-throughput methods were developed using, for example, FACS analysis or microfluidic systems. These achievements significantly facilitate the tailor-made design of… CONTINUE READING
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References

Publications referenced by this paper.
SHOWING 1-10 OF 55 REFERENCES