Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC-MS/MS.

@article{Matuszewski2003StrategiesFT,
  title={Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC-MS/MS.},
  author={Bogdan K. Matuszewski and Marvin L. Constanzer and Cynthia M. Chavez-Eng},
  journal={Analytical chemistry},
  year={2003},
  volume={75 13},
  pages={
          3019-30
        }
}
In recent years, high-performance liquid chromatography (HPLC) with tandem mass spectrometric (MS/MS) detection has been demonstrated to be a powerful technique for the quantitative determination of drugs and metabolites in biological fluids. However, the common and early perception that utilization of HPLC-MS/MS practically guarantees selectivity is being challenged by a number of reported examples of lack of selectivity due to ion suppression or enhancement caused by the sample matrix and… CONTINUE READING
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