Strategies for repair of white matter: influence of osmolarity and microglia on proliferation and apoptosis of oligodendrocyte precursor cells in different basal culture media

@inproceedings{Kleinsimlinghaus2013StrategiesFR,
  title={Strategies for repair of white matter: influence of osmolarity and microglia on proliferation and apoptosis of oligodendrocyte precursor cells in different basal culture media},
  author={Karolina Kleinsimlinghaus and Romy Marx and Meray Serdar and Ivo Bendix and Irmgard D. Dietzel},
  booktitle={Front. Cell. Neurosci.},
  year={2013}
}
The aim of the present study has been to obtain high yields of oligodendrocyte precursor cells (OPCs) in culture. This is a first step in facilitation of myelin repair. We show that, in addition to factors, known to promote proliferation, such as basic fibroblast growth factor (FGF-2) and platelet derived growth factor (PDGF) the choice of the basal medium exerts a significant influence on the yield of OPCs in cultures from newborn rats. During a culture period of up to 9 days we observed… CONTINUE READING

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