Strategies for multilocus linkage analysis in humans.

@article{Lathrop1984StrategiesFM,
  title={Strategies for multilocus linkage analysis in humans.},
  author={G. Mark Lathrop and J. M. Lalouel and C{\'e}cile Julier and Jurg Ott},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1984},
  volume={81 11},
  pages={
          3443-6
        }
}
  • G. Lathrop, J. Lalouel, J. Ott
  • Published 1 June 1984
  • Biology
  • Proceedings of the National Academy of Sciences of the United States of America
The increasing number of DNA polymorphisms characterized in humans will soon allow the construction of fine genetic maps of human chromosomes. This advance calls for a reexamination of current methodologies for linkage analysis by the family method. We have investigated the relative efficiency of two-point and three-point linkage tests for the detection of linkage and the estimation of recombination in a variety of situations. This led us to develop the computer program LINKAGE to perform… 

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