Strategies for developing multi-epitope, subunit-based, chemically synthesized anti-malarial vaccines

@inproceedings{Patarroyo2008StrategiesFD,
  title={Strategies for developing multi-epitope, subunit-based, chemically synthesized anti-malarial vaccines},
  author={Manuel Elkin Patarroyo and Gladys H Cifuentes and Adriana Berm{\'u}dez and Manuel Alfonso Patarroyo},
  booktitle={Journal of cellular and molecular medicine},
  year={2008}
}
An anti-malarial vaccine against the extremely lethal Plasmodium falciparum is desperately needed. Peptides from this parasite's proteins involved in invasion and having high red blood cell-binding ability were identified; these conserved peptides were not immunogenic or protection-inducing when used for immunizing Aotus monkeys. Modifying some critical binding residues in these high-activiy binding peptides' (HABPs') attachment to red blood cells (RBC) allowed them to induce immunogenicity and… CONTINUE READING