Strategies for a comprehensive understanding of metabolism by aldehyde oxidase.

@article{Hutzler2013StrategiesFA,
  title={Strategies for a comprehensive understanding of metabolism by aldehyde oxidase.},
  author={James Matthew Hutzler and R Scott Obach and Deepak K. Dalvie and Michael A. Zientek},
  journal={Expert opinion on drug metabolism & toxicology},
  year={2013},
  volume={9 2},
  pages={153-68}
}
INTRODUCTION Aldehyde oxidase (AO) is a drug-metabolizing molybdo-flavoenzyme with profound species differences in expression and activity toward various substrates. The contribution of this enzyme to the metabolism and clearance of heterocyclic-containing xenobiotics appears to have increased in recent years, but has not always been identified prior to clinical studies. As a result, drug candidates have been negatively impacted in development. AREAS COVERED This review provides the most… CONTINUE READING

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