Strategies for Optimizing Antiepileptic Drug Therapy in Elderly People
@article{Lackner2002StrategiesFO, title={Strategies for Optimizing Antiepileptic Drug Therapy in Elderly People}, author={Thomas E. Lackner}, journal={Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy}, year={2002}, volume={22} }
The elderly take more antiepileptic drugs (AEDs) than all other adults. This extensive use directly correlates with an increased prevalence of epilepsy in a growing population of older people, as well as other neuropsychiatric conditions such as neuropathic pain and behavioral disorders associated with dementia and for which AEDs are administered. The agents account for nearly 10% of all adverse drug reactions in the elderly and are the fourth leading cause of adverse drug reactions in nursing…
38 Citations
Choice of antiepileptic drugs for the elderly: possible drug interactions and adverse effects
- Medicine, PsychologyExpert opinion on drug metabolism & toxicology
- 2012
In order to make further recommendations regarding the choice and dosing regimens of antiepileptic drugs in elderly patients, more extensive clinical research in this specific population is necessary.
Optimizing Antiepileptic Drug Therapy in the Elderly
- MedicineThe Annals of pharmacotherapy
- 2005
Review and evaluation of the medical literature concerning antiepileptic drug (AED) therapy in elderly patients found that elderly patients’ cognitive functioning and their tendency to respond to lower AED concentrations should be made along several lines.
Best clinical and research practice in epilepsy of older people: Focus on antiepileptic drug adherence
- Medicine, PsychologyEpilepsy & Behavior
- 2009
Antiepileptic drugs and bone metabolism
- Medicine, BiologyNutrition & metabolism
- 2006
The pathophysiologic mechanisms of bone disease associated with anti-epileptic use, including effect of anti-Epileptic agents on bone turnover and fracture risk are discussed, highlighting various strategies for prevention of bone loss and associated fractures a rapidly increasing vulnerable population.
Seizure disorders in the elderly.
- Medicine, PsychologyAmerican family physician
- 2003
The goal of antiepileptic drug therapy is to control seizures but preserve quality of life, and drugs for first-line monotherapy of seizures in elderly patients include carbamazepine, valproic acid, oxcarbazepine and gabapentin.
Antiepileptic Drugs and Accumulation of Hospital Days Among Persons With Alzheimer's Disease.
- Medicine, PsychologyJournal of the American Medical Directors Association
- 2019
Adverse drug reactions in elderly patients.
- MedicineBritish journal of clinical pharmacology
- 2004
Age itself should not be used as a reason for withholding adequate doses of effective therapies, and the clear risk of ADRs in this situation should be considered in the context that dose-related failure of existing therapy to manage the condition adequately may be one of the most important reasons for admission of the elderly to hospital.
Management of epilepsy in pediatrics and geriatrics.
- Medicine, PsychologyJournal of the American Pharmaceutical Association
- 2002
Three rare but important conditions among infants and children--pyridoxine-deficiency seizures, Lennox-Gastaut syndrome, and West syndrome--usually require multidrug therapy to control seizures.
Medication-related dizziness in the older adult.
- MedicineOtolaryngologic clinics of North America
- 2011
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