Strategies for Optimizing Antiepileptic Drug Therapy in Elderly People

@article{Lackner2002StrategiesFO,
  title={Strategies for Optimizing Antiepileptic Drug Therapy in Elderly People},
  author={Thomas E. Lackner},
  journal={Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy},
  year={2002},
  volume={22}
}
  • T. Lackner
  • Published 1 March 2002
  • Medicine, Psychology
  • Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy
The elderly take more antiepileptic drugs (AEDs) than all other adults. This extensive use directly correlates with an increased prevalence of epilepsy in a growing population of older people, as well as other neuropsychiatric conditions such as neuropathic pain and behavioral disorders associated with dementia and for which AEDs are administered. The agents account for nearly 10% of all adverse drug reactions in the elderly and are the fourth leading cause of adverse drug reactions in nursing… 
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38 Citations
Highly Influential Citations
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Background Citations
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Methods Citations
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38 Citations

Choice of antiepileptic drugs for the elderly: possible drug interactions and adverse effects

In order to make further recommendations regarding the choice and dosing regimens of antiepileptic drugs in elderly patients, more extensive clinical research in this specific population is necessary.

Optimizing Antiepileptic Drug Therapy in the Elderly

  • W. Garnett
  • Medicine
    The Annals of pharmacotherapy
  • 2005
Review and evaluation of the medical literature concerning antiepileptic drug (AED) therapy in elderly patients found that elderly patients’ cognitive functioning and their tendency to respond to lower AED concentrations should be made along several lines.

Best clinical and research practice in epilepsy of older people: Focus on antiepileptic drug adherence

Overtreatment in adults with epilepsy

  • C. Deckers
  • Medicine, Psychology
    Epilepsy Research
  • 2002

Antiepileptic drugs and bone metabolism

The pathophysiologic mechanisms of bone disease associated with anti-epileptic use, including effect of anti-Epileptic agents on bone turnover and fracture risk are discussed, highlighting various strategies for prevention of bone loss and associated fractures a rapidly increasing vulnerable population.

Seizure disorders in the elderly.

The goal of antiepileptic drug therapy is to control seizures but preserve quality of life, and drugs for first-line monotherapy of seizures in elderly patients include carbamazepine, valproic acid, oxcarbazepine and gabapentin.

Antiepileptic Drugs and Accumulation of Hospital Days Among Persons With Alzheimer's Disease.

Adverse drug reactions in elderly patients.

Age itself should not be used as a reason for withholding adequate doses of effective therapies, and the clear risk of ADRs in this situation should be considered in the context that dose-related failure of existing therapy to manage the condition adequately may be one of the most important reasons for admission of the elderly to hospital.

Management of epilepsy in pediatrics and geriatrics.

  • C. PoonJ. McAuley
  • Medicine, Psychology
    Journal of the American Pharmaceutical Association
  • 2002
Three rare but important conditions among infants and children--pyridoxine-deficiency seizures, Lennox-Gastaut syndrome, and West syndrome--usually require multidrug therapy to control seizures.

Medication-related dizziness in the older adult.

References

SHOWING 1-10 OF 311 REFERENCES

Antiepileptic drug therapy in the elderly.

Use of antiepileptic drugs in the elderly population.

Medical records for 572 patients in two extended care facilities were reviewed to study seizure disorders and antiepileptic drug use and Phenytoin was the most commonly used agent.

Drug-Induced Seizures in the Elderly

A review of drugs that were most commonly associated with inducing seizures in the elderly population and which classes of medications and individual medications are associated with reducing seizure threshold is conducted.

Cognitive and behavioral effects of antiepileptic drugs

Overview of the Safety of Newer Antiepileptic Drugs

The potential for the most recently developed AEDs for producing rare idiosyncratic reactions cannot be ascertained until additional patient exposures have been reported from careful postmarketing surveillance.

Epidemiology, etiology, and treatment of geriatric mania.

  • W. McDonald
  • Medicine, Psychology
    The Journal of clinical psychiatry
  • 2000
The treatment of mania is more difficult in the elderly, and new treatments such as the atypical antipsychotics and the anticonvulsants take on a more important role in treatment regimens for older patients.

Cognitive effects of anticonvulsant monotherapy in elderly patients: a placebo-controlled study

Adverse Reactions to New Anticonvulsant Drugs

The relatively late establishment of aplastic anaemia and hepatic failure as potentially fatal ADRs of felbamate, and of visual field constriction with vigabatrin, should serve as ample reminders that ADRs can appear at any time.

Cognitive Adverse Effects of Antiepileptic Drugs

The newer AEDs (with the exception of zonisamide and topiramate) appear to induced fewer cognitive adverse effects than the older agents, and may also have neuroprotective effects that can prevent seizure-induced neuronal damage, and so reduce cognitive dysfunction.

Clinical pharmacology of antiepileptic drugs. Selected topics.

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