Strategies for Optimizing Antiepileptic Drug Therapy in Elderly People

@article{Lackner2002StrategiesFO,
  title={Strategies for Optimizing Antiepileptic Drug Therapy in Elderly People},
  author={T. Lackner},
  journal={Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy},
  year={2002},
  volume={22}
}
  • T. Lackner
  • Published 2002
  • Medicine
  • Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy
The elderly take more antiepileptic drugs (AEDs) than all other adults. This extensive use directly correlates with an increased prevalence of epilepsy in a growing population of older people, as well as other neuropsychiatric conditions such as neuropathic pain and behavioral disorders associated with dementia and for which AEDs are administered. The agents account for nearly 10% of all adverse drug reactions in the elderly and are the fourth leading cause of adverse drug reactions in nursing… Expand
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Choice of antiepileptic drugs for the elderly: possible drug interactions and adverse effects
TLDR
In order to make further recommendations regarding the choice and dosing regimens of antiepileptic drugs in elderly patients, more extensive clinical research in this specific population is necessary. Expand
Optimizing Antiepileptic Drug Therapy in the Elderly
  • W. Garnett
  • Medicine
  • The Annals of pharmacotherapy
  • 2005
OBJECTIVE To review and evaluate the medical literature concerning antiepileptic drug (AED) therapy in elderly patients. DATA SOURCES A MEDLINE search (1982–December 2004) was conducted.… Expand
Best clinical and research practice in epilepsy of older people: Focus on antiepileptic drug adherence
TLDR
A number of strategies are proposed to improve adherence, including patient education through better communication between physician and patient; simplification of the medical regime; and use of extended-release formulations. Expand
Overtreatment in adults with epilepsy
TLDR
It is suggested that patients with progressive forms of epilepsy, such as patients with mesiotemporal sclerosis, should be treated adequately as soon as possible and that epilepsy surgery should be considered for them in a much earlier stage. Expand
Antiepileptic drugs and bone metabolism
TLDR
The pathophysiologic mechanisms of bone disease associated with anti-epileptic use, including effect of anti-Epileptic agents on bone turnover and fracture risk are discussed, highlighting various strategies for prevention of bone loss and associated fractures a rapidly increasing vulnerable population. Expand
Seizure disorders in the elderly.
TLDR
The goal of antiepileptic drug therapy is to control seizures but preserve quality of life, and drugs for first-line monotherapy of seizures in elderly patients include carbamazepine, valproic acid, oxcarbazepine and gabapentin. Expand
Antiepileptic Drugs and Accumulation of Hospital Days Among Persons With Alzheimer's Disease.
TLDR
AED initiators had more hospital days than noninitiators and pregabalin and gabapentin were associated with a lower number of hospitalDays than valproic acid. Expand
Adverse drug reactions in elderly patients.
TLDR
Age itself should not be used as a reason for withholding adequate doses of effective therapies, and the clear risk of ADRs in this situation should be considered in the context that dose-related failure of existing therapy to manage the condition adequately may be one of the most important reasons for admission of the elderly to hospital. Expand
Management of epilepsy in pediatrics and geriatrics.
TLDR
Three rare but important conditions among infants and children--pyridoxine-deficiency seizures, Lennox-Gastaut syndrome, and West syndrome--usually require multidrug therapy to control seizures. Expand
Medication-related dizziness in the older adult.
TLDR
The evidence evaluated in this review is helpful in clinical practice but requires an additional detailed investigation into the agents discussed to understand the risk/benefit ratio associated with medications. Expand
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