Strategies for MMP inhibition in cancer: innovations for the post-trial era

@article{Overall2002StrategiesFM,
  title={Strategies for MMP inhibition in cancer: innovations for the post-trial era},
  author={Christopher M. Overall and Carlos L{\'o}pez-Ot{\'i}n},
  journal={Nature Reviews Cancer},
  year={2002},
  volume={2},
  pages={657-672}
}
For more than two decades, the view that tumour-associated matrix metalloproteinases (MMPs) were required for peritumour tissue degradation and metastasis dominated the drive to develop MMP inhibitors as anticancer therapeutics. Until recently, clinical trials with MMP inhibitors have yielded disappointing results, highlighting the need for better insight into the mechanisms by which this growing family of multifunctional enzymes contribute to tumour growth. It is now recognized that MMP… CONTINUE READING
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