Strategies for Homology-Based ncRNA Gene Annotation

  • Axel Mosiga, Liang Zhua, Peter F. Stadlerd
  • Published 2009


Most non-coding RNAs are short and/or poorly conserved in sequence. Most of the longer examples, furthermore, consist of a collection of conserved structural motifs rather that a coherent globally conserved secondary structure. As a consequence, the conceptually simple problem of homology search becomes a complex and technically demanding task. Despite the… (More)


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