Strategies employed in the design and optimization of synthetic antimicrobial peptide amphiphiles with enhanced therapeutic potentials.

@article{Ong2014StrategiesEI,
  title={Strategies employed in the design and optimization of synthetic antimicrobial peptide amphiphiles with enhanced therapeutic potentials.},
  author={Zhan Yuin Ong and Nikken Wiradharma and Yi Yan Yang},
  journal={Advanced drug delivery reviews},
  year={2014},
  volume={78},
  pages={28-45}
}
Antimicrobial peptides (AMPs) which predominantly act via membrane active mechanisms have emerged as an exciting class of antimicrobial agents with tremendous potential to overcome the global epidemic of antibiotics-resistant infections. The first generation of AMPs derived from natural sources as diverse as plants, insects and humans has provided a wealth of compositional and structural information to design novel synthetic AMPs with enhanced antimicrobial potencies and selectivities, reduced… CONTINUE READING