Strategies and methodologies for identifying molecular targets in sarcomas and other tumors.

@article{Ravi2005StrategiesAM,
  title={Strategies and methodologies for identifying molecular targets in sarcomas and other tumors.},
  author={Vinod Ravi and Michael K. K. Wong},
  journal={Current treatment options in oncology},
  year={2005},
  volume={6 6},
  pages={487-97}
}
Sarcomas are a heterogeneous group of tumors that respond poorly to conventional cytotoxic chemotherapy. Sarcomas possess specific molecular characteristics that exist because of unique somatic mutations, vital growth factor or growth factor receptor overexpression, or are critically dependent on host pathways. Currently these tumors are classified on the basis of their tissue of origin and histologic appearance. Gene expression and proteomic analysis of sarcomas may enable reclassification of… CONTINUE READING