Strategies and mechanisms for the control of transcriptional initiation of mammalian protein-coding genes.

Abstract

An ability to exercise precise control over a large number of genes, with widely differing patterns of expression, is a requirement for all organisms and this ability reaches its most sophisticated level in mammalian systems. Although there are numerous examples of control being exerted at every stage along the expression pathway, the key control point in most instances appears to be at the first stage of the process the transcriptional initiation event itself. The purpose of this article is to provide a brief overview of current ideas on the control of transcriptional initiation in mammalian cells, both in the context of recent developments in mammalian systems and by analog}' with more advanced studies in prokaryotes and yeast. (See Ptashne, 1986; Struhl, 1987, for reviews on transcriptional initiation in bacteria and yeast, respectively.)

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Cite this paper

@article{Melton1987StrategiesAM, title={Strategies and mechanisms for the control of transcriptional initiation of mammalian protein-coding genes.}, author={David W. Melton}, journal={Journal of cell science}, year={1987}, volume={88 ( Pt 3)}, pages={267-70} }