Strategies and challenges for the next generation of antibody–drug conjugates

@article{Beck2017StrategiesAC,
  title={Strategies and challenges for the next generation of antibody–drug conjugates},
  author={Alain Beck and Liliane Goetsch and Charles Dumontet and Nathalie Corvaïa},
  journal={Nature Reviews Drug Discovery},
  year={2017},
  volume={16},
  pages={315-337}
}
Antibody–drug conjugates (ADCs) are one of the fastest growing classes of oncology therapeutics. After half a century of research, the approvals of brentuximab vedotin (in 2011) and trastuzumab emtansine (in 2013) have paved the way for ongoing clinical trials that are evaluating more than 60 further ADC candidates. The limited success of first-generation ADCs (developed in the early 2000s) informed strategies to bring second-generation ADCs to the market, which have higher levels of cytotoxic… 
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