Strategies and Molecular Probes to Investigate the Role of Cytochrome P450 in Drug Metabolism

@article{Donato2003StrategiesAM,
  title={Strategies and Molecular Probes to Investigate the Role of Cytochrome P450 in Drug Metabolism},
  author={Mar{\'i}a Teresa Donato and Jose V Castell},
  journal={Clinical Pharmacokinetics},
  year={2003},
  volume={42},
  pages={153-178}
}
Drug metabolism is the major determinant of drug clearance and, because of polymorphic or inducible expression of drug-metabolising cytochrome P450s (CYPs), is the factor most frequently responsible for interindividual differences in pharmacokinetics. A number of well characterised CYP substrates and inhibitors have been identified that allow precise measurements of individual CYP isoforms. Their use, alone or in combination, facilitates the phenotype characterisation of hepatocytes in vitro… CONTINUE READING

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