Strategically targeting MYC in cancer

  title={Strategically targeting MYC in cancer},
  author={Valeriya Posternak and Michael D. Cole},
MYC is a major driver of cancer cell growth and mediates a transcriptional program spanning cell growth, the cell cycle, metabolism, and cell survival. Many efforts have been made to deliberately target MYC for cancer therapy. A variety of compounds have been generated to inhibit MYC function or stability, either directly or indirectly. The most direct inhibitors target the interaction between MYC and MAX, which is required for DNA binding. Unfortunately, these compounds do not have the desired… CONTINUE READING
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