Strategic use of affinity-based mass spectrometry techniques in the drug discovery process.

@article{Kelly2002StrategicUO,
  title={Strategic use of affinity-based mass spectrometry techniques in the drug discovery process.},
  author={Michele A Kelly and Thomas J. McLellan and Philip J Rosner},
  journal={Analytical chemistry},
  year={2002},
  volume={74 1},
  pages={
          1-9
        }
}
Advances in biomolecular mass spectrometry (Bio-MS) have made this technique an invaluable tool for analytical chemists and biochemists alike. The applicability of Bio-MS approaches in drug discovery now encompasses in vitro, cellular, and in vivo pharmacological and clinical applications in an unprecedented expansion of utility. As a result, the role of Bio-MS in pharmaceutical discovery continues to proliferate for both structural and functional characterization of biomolecules. From target… CONTINUE READING