Strategic localization of heart mitochondrial NOS: a review of the evidence.

@article{Zaobornyj2012StrategicLO,
  title={Strategic localization of heart mitochondrial NOS: a review of the evidence.},
  author={Tamara Zaobornyj and Pedram Ghafourifar},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2012},
  volume={303 11},
  pages={H1283-93}
}
Heart mitochondria play a central role in cell energy provision and in signaling. Nitric oxide (NO) is a free radical with primary regulatory functions in the heart and involved in a broad array of key processes in cardiac metabolism. Specific NO synthase (NOS) isoforms are confined to distinct locations in cardiomyocytes. The present article reviews the chemical reactions through which NO interacts with biomolecules and exerts some of its crucial roles. Specifically, the article discusses the… CONTINUE READING

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