Strategic Approach to 8-Azacoumarins.


8-Azacoumarins have emerged as a promising class of compounds but are rarely explored due to challenging access. A novel, general, and practical method is provided for this class of compounds. The key lactonization step employs trans-acrylic acid attached pyridine N-oxides as the starting material, with acetic anhydride as both the activation agent and the… (More)
DOI: 10.1021/acs.orglett.6b03771


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