Strand specificity and absence of hot spots for p53 mutations in ultraviolet B-induced skin tumors of XPA-deficient mice.

@article{Takeuchi1998StrandSA,
  title={Strand specificity and absence of hot spots for p53 mutations in ultraviolet B-induced skin tumors of XPA-deficient mice.},
  author={Seiji Takeuchi and Yoshimichi Nakatsu and Hironobu Nakane and Hiroaki Murai and Seiichi Hirota and Yukihiko Kitamura and Akihiko Okuyama and Kiyoko Tanaka},
  journal={Cancer research},
  year={1998},
  volume={58 4},
  pages={641-6}
}
We examined the spectrum of p53 mutations found in 40 UV-induced skin tumors of xeroderma pigmentosum group A gene (XPA)-deficient mice. p53 mutations were detected in 48% of the tumors. Nearly all of the mutations were induced at dipyrimidine sites. Ninety-three % of the mutations were G.C-->A.T transitions at dipyrimidine sites, including tandem transitions (CC-->TT), which are the hallmark of the UVB-induced mutation. Seventy-two % of the mutations at dipyrimidine sites could be ascribed to… CONTINUE READING

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