Strand invasion structures in the inverted repeat of Candida albicans mitochondrial DNA reveal a role for homologous recombination in replication.

@article{Gerhold2010StrandIS,
  title={Strand invasion structures in the inverted repeat of Candida albicans mitochondrial DNA reveal a role for homologous recombination in replication.},
  author={Joachim M Gerhold and Anu Aun and Tiina Sedman and Priit J{\~o}ers and Juhan Sedman},
  journal={Molecular cell},
  year={2010},
  volume={39 6},
  pages={851-61}
}
Molecular recombination and transcription are proposed mechanisms to initiate mitochondrial DNA (mtDNA) replication in yeast. We conducted a comprehensive analysis of mtDNA from the yeast Candida albicans. Two-dimensional agarose gel electrophoresis of mtDNA intermediates reveals no bubble structures diagnostic of specific replication origins, but rather supports recombination-driven replication initiation of mtDNA in yeast. Specific species of Y structures together with DNA copy number… CONTINUE READING

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