Strand invasion properties and serum stability of alpha-tricyclo-DNA.

Abstract

beta-tricyclo DNA (tcDNA) is a third generation antisense oligonucleotide developed and studied extensively in our laboratory. We recently became interested in the pairing properties of its alpha-anomeric form and observed parallel duplex formation with natural DNA and RNA. These duplexes were of the same level of thermal stability as their natural… (More)
DOI: 10.1093/nass/nrn071

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