Strains of Escherichia coli O157:H7 differ primarily by insertions or deletions, not single-nucleotide polymorphisms.

@article{Kudva2002StrainsOE,
  title={Strains of Escherichia coli O157:H7 differ primarily by insertions or deletions, not single-nucleotide polymorphisms.},
  author={Indira T. Kudva and Peter S. Evans and Nicole T. Perna and Timothy J. Barrett and Frederick M. Ausubel and Frederick R. Blattner and Stephen B. Calderwood},
  journal={Journal of bacteriology},
  year={2002},
  volume={184 7},
  pages={
          1873-9
        }
}
Escherichia coli O157:H7 (O157) strains demonstrate varied pulsed-field gel electrophoresis patterns following XbaI digestion, which enable epidemiological surveillance of this important human pathogen. The genetic events underlying PFGE differences between strains, however, are not defined. We investigated the mechanisms for strain variation in O157 by recovering and examining nucleotide sequences flanking each of the XbaI restriction enzyme sites in the genome. Our analysis demonstrated that… CONTINUE READING
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