Strained cyclophane macrocycles: impact of progressive ring size reduction on synthesis and structure.


The synthesis, X-ray crystal structures, and calculated strain energies are reported for a homologous series of 11- to 14-membered drug-like cyclophane macrocycles, representing an unusual region of chemical space that can be difficult to access synthetically. The ratio of macrocycle to dimer, generated via a copper catalyzed azide-alkyne cycloaddition… (More)
DOI: 10.1021/ja208503y


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