Strain theory of malaria: the first 50 years.

@article{McKenzie2008StrainTO,
  title={Strain theory of malaria: the first 50 years.},
  author={F. Ellis McKenzie and David L. Smith and Wendy Prudhomme O'Meara and Eleanor M. Riley},
  journal={Advances in parasitology},
  year={2008},
  volume={66},
  pages={1-46}
}
From the 1920s to the 1970s, a large body of principles and evidence accumulated about the existence and character of 'strains' among the Plasmodium species responsible for human malaria. An extensive research literature examined the degree to which strains were autonomous, stable biological entities, distinguishable by clinical, epidemiological or other features, and how this knowledge could be used to benefit medical and public health practice. Strain theory in this era was based largely on… CONTINUE READING

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