[Strain-specific response in mice to the neonatal administration of ACTH(4-10) fragment: behavior, neurochemistry, and brain morphology].

Abstract

Neonatal injection of the ACTH4-10 fragment (5 micrograms daily for five days) caused genotype-dependent changes in concentrations of some monoaminergic neuromediators and their metabolites in hippocampus and brain stem of adult CBA and 101/HY mice. The catecholaminergic neurons increased in number in hypothalamic zona incerta of adult 101/HY mice. Neonatal injection of the peptide caused also genotype-dependent changes in the exploratory behavior of adult animals. Sound sensitivity was reduced in the 101/HY mice, whereas no sensitivity was revealed in both control and experimental groups of the CBA mice. The effects discovered were suggested to be caused by changes in neuronal differentiation.

Cite this paper

@article{Shilova2000StrainspecificRI, title={[Strain-specific response in mice to the neonatal administration of ACTH(4-10) fragment: behavior, neurochemistry, and brain morphology].}, author={O. B. Shilova and E O Orlova and Georgy I. Kovalev and Alexander V. Revishchin and Irina G. Lil'p and Inga I. Poletaeva and Leonid Ivanovich Korochkin}, journal={Genetika}, year={2000}, volume={36 11}, pages={1507-14} }