Strain-specific effects of rosiglitazone on bone mass, body composition, and serum insulin-like growth factor-I.

@article{AckertBicknell2009StrainspecificEO,
  title={Strain-specific effects of rosiglitazone on bone mass, body composition, and serum insulin-like growth factor-I.},
  author={Cheryl L. Ackert-Bicknell and Keith R. Shockley and Lindsay G Horton and Beata Lecka-Czernik and Gary A. Churchill and Clifford J. Rosen},
  journal={Endocrinology},
  year={2009},
  volume={150 3},
  pages={1330-40}
}
Activation of peroxisome proliferator activated receptor-gamma (PPARG) is required for the differentiation of marrow mesenchymal stem cell into adipocytes and is associated with the development of age-related marrow adiposity in mice. Thiazolidinediones are agonists for PPARG and have a heterogeneous effect on bone mineral density (BMD). We postulated that genetic determinants influence the skeletal response to thiazolidinediones. We examined the effects of rosiglitazone (3 mg/kg . d for 8 wk… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 27 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 48 references

Similar Papers

Loading similar papers…