Strain sensitivity differences in the Hershberger assay.

@article{Yamasaki2001StrainSD,
  title={Strain sensitivity differences in the Hershberger assay.},
  author={Kanji Yamasaki and Masakuni Sawaki and Mineo Takatsuki},
  journal={Reproductive toxicology},
  year={2001},
  volume={15 4},
  pages={
          437-40
        }
}
The Hershberger assay is a test method for detecting androgenic or antiandrogenic properties based on alterations in the weights of accessory sex organs in castrate male animals. We performed this study to examine strain sensitivity differences in the Hershberger assay. Flutamide (FLU) at a dose of 3.2 mg/kg was administered to castrated F344, SD, or Wistar rats, in addition to testosterone propionate (TP) administered at a dose of 0.4 mg/kg. Although FLU significantly attenuated the TP-induced… CONTINUE READING