Strain rate imaging detects early cardiac effects of pegylated liposomal Doxorubicin as adjuvant therapy in elderly patients with breast cancer.

@article{Jurcut2008StrainRI,
  title={Strain rate imaging detects early cardiac effects of pegylated liposomal Doxorubicin as adjuvant therapy in elderly patients with breast cancer.},
  author={Ruxandra Jurcut and Hans Wildiers and Javier Ganame and Jan D'hooge and Julie De Backer and Hannelore Denys and Robert J. Paridaens and Frank E. Rademakers and J urgen Voigt},
  journal={Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography},
  year={2008},
  volume={21 12},
  pages={1283-9}
}
OBJECTIVE Cardiac toxicity remains an important side effect of anthracyclines. New drug formulations (eg, pegylated liposomal doxorubicin [PL-DOX]) seem to be a successful strategy for reducing it. Changes in cardiac function induced by early chemotherapy, however, are subtle and difficult to quantitate by conventional imaging methods. Doppler myocardial imaging-based velocity, strain, and strain rate measurements have been shown to sensitively quantify abnormalities in cardiac function in… CONTINUE READING

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