Strain prevalence, rather than innate virulence potential, is the major factor responsible for an increase in serious group A streptococcus infections.

@article{Rogers2007StrainPR,
  title={Strain prevalence, rather than innate virulence potential, is the major factor responsible for an increase in serious group A streptococcus infections.},
  author={Susan D. Rogers and Robert James Commons and Margaret H Danchin and Gowri Selvaraj and Loraine Kelpie and Nigel Curtis and Roy M Robins-Browne and Jonathan Carapetis},
  journal={The Journal of infectious diseases},
  year={2007},
  volume={195 11},
  pages={
          1625-33
        }
}
BACKGROUND It is postulated that the surge in incidence and severity of group A streptococcus (GAS) infections since the 1980s is due to the emergence of strains of GAS with increased virulence. We used active, population-based surveillance of invasive GAS disease, serologically confirmed pharyngitis, and carriage to determine whether particular strains were associated with invasive disease. METHODS Two hundred twenty GAS isolates were collected--78 invasive, 34 pharyngitis, and 108 carriage… CONTINUE READING

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CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 46 REFERENCES

Invasive group A streptococcal disease in North Queensland (1996 - 2001).

  • The Indian journal of medical research
  • 2004
VIEW 7 EXCERPTS
HIGHLY INFLUENTIAL

Epidemiology of invasive group a streptococcus disease in the United States, 1995-1999.

  • Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 2002
VIEW 8 EXCERPTS
HIGHLY INFLUENTIAL

Streptococcus pyogenes causing toxic-shock-like syndrome and other invasive diseases: clonal diversity and pyrogenic exotoxin expression.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 1991
VIEW 8 EXCERPTS
HIGHLY INFLUENTIAL