Strain improvement in actinomycetes in the postgenomic era

  title={Strain improvement in actinomycetes in the postgenomic era},
  author={Richard H. Baltz},
  journal={Journal of Industrial Microbiology & Biotechnology},
With the recent advances in DNA sequencing technologies, it is now feasible to sequence multiple actinomycete genomes rapidly and inexpensively. An important observation that emerged from early Streptomyces genome sequencing projects was that each strain contains genes that encode 20 or more potential secondary metabolites, only a fraction of which are expressed during fermentation. More recently, this observation has been extended to many other actinomycetes with large genomes. The discovery… CONTINUE READING

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Molecular genetic approaches to yield improvement in actinomycetes

  • RH Baltz
  • Drug Pharmaceutical Sci
  • 1997
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