Strain distribution pattern of susceptibility to immune-mediated nephritis.

@article{Xie2004StrainDP,
  title={Strain distribution pattern of susceptibility to immune-mediated nephritis.},
  author={Chun Lin Xie and Ruchi Sharma and Hongwei Wang and Xin J. Zhou and Chandra Mohan},
  journal={Journal of immunology},
  year={2004},
  volume={172 8},
  pages={
          5047-55
        }
}
The genetic basis of immune-mediated nephritis is poorly understood. Recent studies have demonstrated that the NZW mouse strain is more prone to immune-mediated nephritis compared with C57BL/6 and BALB/c strains. The present study extends these findings by challenging 12 additional inbred strains of mice with rabbit anti-mouse glomerular basement membrane (GBM) reactive sera. Compared with control sera-injected mice and anti-GBM-injected A/J, AKR/J, C3H/HeJ, DBA/2J, MRL/MpJ, NOD/LtJ, P/J, SJL/J… CONTINUE READING

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