Strain differences in toxicity of oral cadmium intake in rats.

  title={Strain differences in toxicity of oral cadmium intake in rats.},
  author={M Jordana Ninkov and Aleksandra Popov Aleksandrov and Ivana Mirkov and Jelena Demenesku and Dina Mileusnic and Sofija Jovanovi{\'c} Stojanov and Nata{\vs}a Goli{\'c} and Maja Tolina{\vc}ki and Lidija Zolotarevski and Dragan Kataranovski and Ilija D Br{\vc}eski and Milena Kataranovski},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
Influence of genetic background on toxicity of oral cadmium (Cd) administration (30 days, in drinking water; 5 ppm and 50 ppm of cadmium) was examined in Albino Oxford (AO) and Dark Agouti (DA) rats. Similar cadmium deposition was noted in gut and draining mesenteric lymph nodes (MLN) of both strains but intensity and/or the pattern of responses to cadmium in these tissues differ. Less intense intestinal damage and leukocyte infiltration was observed in gut of cadmium-exposed AO rats. While gut… CONTINUE READING


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