Strain differences in the susceptibility to azoxymethane and dextran sodium sulfate-induced colon carcinogenesis in mice.

@article{Suzuki2006StrainDI,
  title={Strain differences in the susceptibility to azoxymethane and dextran sodium sulfate-induced colon carcinogenesis in mice.},
  author={Rikako Suzuki and Hiroyuki Kohno and Shigeyuki Sugie and Hitoshi Nakagama and Takuji Tanaka},
  journal={Carcinogenesis},
  year={2006},
  volume={27 1},
  pages={
          162-9
        }
}
We have recently developed a mouse model for colitis-related colon carcinogenesis by a combined treatment with azoxymethane (AOM) and dextran sodium sulfate (DSS) in male ICR mice. However, strain differences in the sensitivity to AOM/DSS-induced colon carcinogenesis in mice have yet to be elucidated. The aim of this study was to determine the presence of any genetically determined differences in sensitivity to our model of colon carcinogenesis in four inbred strains of mice. Male Balb/c, C3H… 
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Colon carcinogenesis in wild type and immune compromised mice after treatment with azoxymethane, and azoxymethane with dextran sodium sulfate
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The induction of colon tumors was evaluated in wild type and athymic BALB/c mice treated with the colon carcinogen azoxymethane as a single agent and in an inflammation model of colon cancer employing AOM and dextran sodium sulfate (DSS).
The Effect of Sex on the Azoxymethane/Dextran Sulfate Sodium-treated Mice Model of Colon Cancer
TLDR
In AOM/DSS murine model, colitis-associated colon tumorigenesis are induced more severely in male mice than female probably by way of inflammatory mediators such as IL-1β and MPO.
A Novel Modified Model for Induction of Intestinal Adenomas in Female Mice
TLDR
Results suggest that the administration of three, 5-day, cycles of 2.5% DSS following an initial dose of AOM may successfully induce adenoma formation in female C57BL6 mice at day 60, without the concurrent presence of carcinoma.
Global gene expression analysis of the mouse colonic mucosa treated with azoxymethane and dextran sodium sulfate
TLDR
This is the first report describing global gene expression analysis of an AOM/DSS-induced mouse Colon carcinogenesis model, and the findings provide new insights into the mechanisms of inflammation-related colon carcinogenesis and the establishment of novel therapies and preventative strategies against carcinogenesis.
A Novel Modification of the AOM/DSS Model for Inducing Intestinal Adenomas in Mice
TLDR
The results suggest that the administration of three 5-day cycles of 2.5% DSS following an initial dose of AOM may successfully induce adenoma formation without the concurrent presence of carcinoma in female C57BL6 mice that are sacrificed on experimental day 60.
Induction of colorectal carcinogenesis in the C57BL/6J and A/J mouse strains with a reduced DSS dose in the AOM/DSS model
TLDR
It is shown that colonic preneoplastic lesions can be reliably detected in A/J and B6 mice by use of a AOM/DSS model involving a single injection of 10 mg/kg AOM followed by three 7-day cycles of a low-dose (1%) DSS administration.
Loss of sulfiredoxin renders mice resistant to azoxymethane/dextran sulfate sodium-induced colon carcinogenesis.
TLDR
The first in vivo evidence that loss of Srx renders mice resistant to AOM/DSS-induced colon carcinogenesis is provided, suggesting that Srx has a critical oncogenic role in cancer development, and Srx may be used as a marker for human colon cancer pathogenicity.
Mouse strain differences in inflammatory responses of colonic mucosa induced by dextran sulfate sodium cause differential susceptibility to PhIP‐induced large bowel carcinogenesis
TLDR
The present results provide strong evidence that prolonged chronic inflammatory responses induced by DSS are directly responsible for the observed enhancement of PhIP‐induced large bowel carcinogenicity.
Effects of 17β-estradiol on colorectal cancer development after azoxymethane/dextran sulfate sodium treatment of ovariectomized mice.
Melatonin suppresses AOM/DSS-induced large bowel oncogenesis in rats.
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